- P1: Phase 1 of the Grand Challenge (Awarded in February 2018)
- P2: Phase 2 of the Grand Challenge (Awarded in October 2018)
- REDSURF: The Racial and Ethnic Disparities in Substance Use Research Fund of the Grand Challenge (Awarded in 2022 and 2023)
Funded Projects
Improving the Substance Use Care Cascade in the Juvenile Justice System
Matthew Aalsma, professor of pediatrics and psychology in the IU School of Medicine: Determine best practices for implementing screening, intervention, and substance use disorder treatment services to incarcerated juveniles in counties across Indiana. (P1)
Telehealth Recovery and Resilience Program—Opioid Extension 9TRPP-O in Adolescent and Young Adult Trauma Survivors
Zachary Adams, assistant professor of clinical psychology in the IU School of Medicine: Adapt and evaluate a technology-based stepped care intervention to facilitate treatment access for young people with problematic substance use and related comorbidities (PTSD, depression, pain) following traumatic injury, thereby reducing substance use disorders. (P2)
PharmNet: Strengthening Overdose and HIV/HCV Prevention Access
Jon Agley, associate professor of applied health science in the School of Public Health-Bloomington: Execute a statewide public health intervention that aims to increase the diagnosis of opioid addiction, reduce opioid overdose mortality, HIV and hepatitis C among people who inject drugs, and strengthen the system of prevention and treatment for opioid users. (P1)
Modeling the Impact of Early Life Environmental Living Conditions on Drug Intake and Related Behavior
Stephen Boehm, professor of psychology in the School of Science at IUPUI: Identify unique risk factors in the development of alcohol, marijuana, and opioid addiction, researching how external and environmental conditions contribute to addictions disparities in Indiana and beyond. (P1)
Noninvasive Deep Neurostimulation Treatment for Addiction
Joshua Brown, associate professor of psychological and brain sciences in the IU Bloomington College of Arts and Sciences; Peter Finn, professor of psychological and brain sciences in the IU Bloomington College of Arts and Sciences; Leslie Hulvershorn, associate professor of psychiatry in the IU School of Medicine: Develop novel neurostimulation using temporal interference technology to treat SUDs, with the long-term goal of developing a lightweight, inexpensive headband that can suppress the wearer's cravings and support drug abstinence indefinitely. (P2)
Investigating Best Practices for Research Recruitment and Retention Among Reproductive Aged Black Women (18-44) With Opioid Use Disorder
Angela Campbell, assistant professor of applied health science, School of Public Health-Bloomington: Determine best practices for recruitment and retention of reproductive aged Black women with OUD for future qualitative work examining the patient experience of this population. (REDSURF)
Characterizing the Course of Long-Term Opioid Use Disorder Recovery and the Impact of Medication- Assisted Treatment on Opioid Use Disorder Recovery
Melissa Cyders, associate professor of psychology in the School of Science at IUPUI: Reduce OUD overdose and incidence by developing a comprehensive guide to best practices for MAT in long-term OUD recovery and by characterizing normative data on recovery course that can guide appropriate recovery expectations and reduce stigma. (P2)
Computer Adaptive Testing
Brian D'Onofrio, professor of psychological and brain sciences in the IU Bloomington College of Arts and Sciences: Demonstrate the effectiveness of implementing an innovative, computerized assessment tool to identify and predict substance use disorders in multiple community settings. (P1)
ADHD Medication and Major Substance Problems: Exploring Minoritized Racial/Ethnic and Vulnerable Youth in National Medicaid Data
Brian D'Onofrio, professor of psychological and brain sciences in the IU Bloomington College of Arts and Sciences: Examine the racial and ethnic differences in the effects of ADHD medication treatment on major substance use problems in a dataset including all youth and young adults insured by Medicaid in the United States. (REDSURF)
2018 Indiana Public Health Conference
Joan Duwve, (former) associate dean for practice and associate professor of health policy and management at the Fairbanks School of Public Health at IUPUI: Hosted the 2018 Public Health Conference, which focused on reframing harm reduction as a public health imperative. More than 300 people attended the conference and 35 people attended a pre-conference. Sixty-one people attended a naloxone training event at the conference. (P1)
The Indiana Addictions Data Commons
Peter Embi, president and CEO of the Regenstrief Institute and the Sam Regenstrief Professor of Medicine at the IU School of Medicine: Develop a state-of-the-art "data commons" infrastructure that streamlines the standardization, integration, and circulation of critical health data, including key environmental, behavioral, community, and other valuable data that are not routinely collected by health care systems. (P1)
IN-PORT: Indiana Networks of Prescribers of Opioids and Related Treatments
Hank Green, associate professor of applied health sciences in the School of Public Health-Bloomington: Explain patterns of over-prescribing of opioids and under-prescribing of MAT by analyzing claims data from a large commercially insured population over ten years to test whether opioid and MAT prescribing varies based on multiple factors. (P2)
Accelerating Solutions to the Opioid Epidemic by Repurposing a Cannabinoid CB2 Agonist
Andrea Hohmann, Gill Chair and professor of psychological and brain sciences in the IU Bloomington College of Arts and Sciences: Conduct preclinical studies required to validate and repurpose a former osteoarthritis drug clinical candidate as a novel analgesic strategy that suppresses opioid tolerance and physical dependence. (P2)
Engaging College Students of Color as Partners in Research on the Protective Processes in Decisions to Drink Alcohol
Peter Finn, psychological and brain sciences in the IU Bloomington College of Arts and Sciences: Engage the Black student community at IUB and IUPUI in order to more fully understand the specific social contexts and specific processes that may differentially affect drinking decisions in Black college students compared with Caucasians as a means for understanding both protective and risk factors in young adults' drinking decision making. (REDSURF)
Did the COVID-19 Public Health Emergency (PHE) Medicaid Continuity Help Reduce Racial/Ethnic Gaps in Postpartum Access to Treatment for Opioid Use Disorder?
Sumedha Gupta, associate professor of economics in the School of Liberal Arts at IUPUI: Examine whether the federal and state laws from 2020 onwards extending Medicaid health insurance coverage to the post-partum period improved access to treatment for opioid use disorder (OUD) and reduced racial disparities, using electronic health records from the Indiana Network for Patient Care (INPC). (REDSURF)
Predicting Young Adults' Completion of Substance Use Treatment by Race and Ethnicity: A Machine Learning Approach
Saahoon Hong, assistant research professor in the IU School of Social Work at IUPUI; Betty Walton, associate research professor in the School of Social Work at IUPUI; Hea-won Kim, associate professor in the IU School of Social Work at IUPUI: enhance the knowledge and understanding of the racial and ethnic disparities in substance use disorder (SUD) treatment completion with the application of machine learning methods. (REDSURF)
Vitamin D and Opioid Use: From Real-World Data to Clinical Practice
Xin Li, visiting assistant professor of epidemiology in the Fairbanks School of Public Health at IUPUI: Conduct a pilot study among patients seeking methadone maintenance treatment to investigate whether vitamin D supplementation could improve treatment retention and reduce opioid use. (P2)
Can State Policy and Market Competition Affect Opioid Prescribing? The Role of Physician Behaviors in Rural vs. Urban Settings
Hsien-Chang Lin, associate professor in the School of Public Health-Bloomington: Investigate the policy implications of initiatives designed to decrease the availability of prescribed opioids in rural and urban communities to improve the impact of policy and law on Indiana's substance use crisis. (P1)
A Community-Based Addiction Reduction Plus Policy Innovations Program for Indiana
Debra Litzelman, D. Craig Brater Professor of Medicine at the IU School of Medicine: Support and enable opiate-addicted parents to engage in substance use and mental health treatment through the workforce development of community health workers. (P1)
A Comprehensive Perinatal (COPE) Program for women with SUD
Debra Litzelman, D. Craig Brater Professor of Medicine at the IU School of Medicine: Build an addiction recovery support program for women with substance use disorder building on behavioral change interventions for women from high-risk populations for adverse pregnancy outcomes, and permit implementation and dissemination of an addiction reduction and recovery model in Central Indiana for eventual statewide adoption. (REDSURF)
Chemical Surveillance System for the Synthetic Drug Crisis
Nicholas Manicke, assistant professor of chemistry and chemical biology in the School of Science at IUPUI: Use novel technology which significantly simplifies synthetic drug testing to develop a monitoring program to identify the drug compounds causing emergency department visits and link them to important clinical and location data. (P2)
IUI ECHO Center
Joan Duwve, Former Associate Dean for Public Health Practice and Professor of Health Management and Policy: Implement a web-based learning hub that empowers local clinicians through expert medical education to help meet the need for diagnosis, treatment, and extended care for patients throughout the state. Launched ECHO hubs for treatment of Hepatitis C and HIV, which are closely linked to substance use; launched ECHO programs in transgender health (because LGBTQ persons are more likely to develop addictions), peer education, integrated pain management, cancer prevention and survivorship care, and community recovery efforts. (P1)
Black Maternal Health ECHO
Gerardo Maupomé, associate dean for research and professor of social and behavioral sciences at the Fairbanks School of Public Health at IUPUI and Andrea Janota, IUI ECHO Center Director: Engage communities and interdisciplinary providers with the goals of engendering shared decision-making and incorporation of equitable healthcare practices for Black pregnant people. (REDSURF)
Opioid Use, Substance Use Disorders, and Opioid Overdose Outcomes after Traumatic Injury in Adolescents
Teresa Bell, assistant professor of surgery, and Olena Mazurenko, associate professor of global health and health policy and management, Fairbanks School of Public Health at IUPUI: Identify the predictors of sustained opioid use, opioid abuse, and opioid overdose in order to reduce future substance abuse disorders in adolescents that experienced a traumatic injury. (P1)
Stigma and Racial Disparities in Neonatal Drug Toxicology Screening
Cydney McGuire, assistant professor in the IU Bloomington O'Neill School of Public and Environmental Affairs: use quantitative and qualitative research methods to assess the extent to which racial patterns in neonatal drug testing rates are indicative of credible child protection goals vs. stigma, clinician bias, or institutionalized racism. (REDSURF)
Addressing Racial and Ethnic Disparities in Substance Use through Integration of Motivational Interviewing in Faith-Based Settings
Hope McMickle, research associate in the department of applied health science in the School of Public Health-Bloomington: Explore the utility of Motivational Interviewing (MI) and MI-derived motivational enhancement techniques (MET) versus traditional health education sessions conducted by lay health volunteers in predominantly African American faith-based settings in increasing motivation, readiness, and perceived ability and confidence for change in areas including substance use, misuse, and abuse. (REDSURF)
Workforce and Capacity Assessment for People Referred to Treatment Post Hospital Discharge
Robin Newhouse, dean and distinguished professor at the IU School of Nursing: Evaluate the current treatment capacity landscape across the state, recommending strategies that build workforce and treatment capacity and create an action network of nurses throughout Indiana. (P1)
Can State-Mandated Information on Prescription History Reduce Racial Bias in Prescribing
Alberto Ortega, assistant professor in the IU Bloomington O'Neill School of Public and Environmental Affairs: Examine the causal impact of Prescription Drug Monitoring Program (PDMP) laws on prescribing for Black patients relative to white patients, examining whether PDMPs are associated with overdose mortality for the Black population and advancing knowledge about racialized impacts of prevalent policies used in the opioid crisis. (REDSURF)
Opioid Addiction and Public Stigma: An Assessment of Rural and Urban Indiana Communities
Brea Perry, professor of sociology in the IU Bloomington College of Arts and Sciences; Anne C. Krendl, associate professor of psychological and brain sciences in the IU Bloomington College of Arts and Sciences: Identify the nature and magnitude of addiction stigma in Indiana by surveying local county residents, including opioid users, to evaluate self-stigma and its social, economic, and health consequences in Indiana communities. (P2)
Hidden Mortality and Multilevel Influences in Indiana's Opioid Epidemic: Hot Spots and Hot Links
Bernice Pescosolido, distinguished professor of sociology in the IU Bloomington College of Arts and Sciences; Brea Perry, professor of sociology in the IU Bloomington College of Arts and Sciences: Leverage developments in data analysis and integration to investigate potential "hot spots" in other death classifications and provide new insights on "hot links" to opioid deaths. (P2)
Leveraging Interprofessional Education to Improve Training for Future Health Professionals in Pain Management, Alternatives to Opioids and Better Prescribing Practices
Andrea Pfeifle, associate professor of family medicine, and Laura Romito, professor of biomedical and applied sciences at the IU School of Dentistry: Increase and improve the training of health care professionals from IU, emphasizing a systems-based approach that addresses opioid substance abuse disorder and overdose through screening, prevention, diagnosis, treatment and harm reduction, appropriate referral, and effective pain management. Launched the Comprehensive Pain Assessment Clinic at IU Family Medicine Center in Indianapolis. (P1)
Advanced Analytics for IU's Addictions Grand Challenge
Titus Schleyer, professor of biomedical informatics in the IU School of Medicine; Katy Börner, distinguished professor of information science in the IU Bloomington School of Informatics, Computing and Engineering: Develop ways to analyze and visualize data related to the opioid epidemic, ultimately creating a foundational platform for research, policy development, and practical interventions. (P2)
Community Conditions, Practices, and Beliefs Contributing to Inequitable Opioid Overdose Education and Response in Black-Dominant Indianapolis Communities
Dong Chul Seo, professor of applied health science in the School of Public Health-Bloomington; Conduct in-depth and focus group interviews with key informants in four Indianapolis zip code areas where overdose rates disproportionately affect Black residents, to understand the community conditions, policies, practices, misinformation, and stigmatizing beliefs that contribute to inequitable opioid overdose education and response. (REDSURF)
Legal and Policy Best Practices in Response to the Opioid Epidemic
Ross D. Silverman, professor of health policy and management at the Fairbanks School of Public Health and professor of public health and law at the IU Robert H. McKinney School of Law at IUPUI; Nicolas P. Terry, Hall Render Professor of Law and executive director, Hall Center for Law and Health: Conducted a multiphase research analysis to develop evidence-based law and policy interventions that improve substance use health outcomes. Worked with law and policy experts to identify and assess opportunities to improve the effectiveness of Indiana law and policy implicated in the state’s response to the opioid crisis; issued first report in 2018; continue to analyze legal, regulatory, and policy barriers to prevention, treatment, and recovery so as to recommend additional beneficial interventions. (P1)
The Addictions Law and Policy Surveillance Project
Ross Silverman, professor of health policy and management in the Fairbanks School of Public Health and professor of public health and law at the IU Robert H. McKinney School of Law at IUPUI: Analyze the content, implementation, and impact of local, state, and national laws and policies related to addiction; evaluate the implementation of laws, policies, and programs and their impact on professional practices, the health of Hoosiers, and addictions crisis response. (P2)
Opioid Addictions and the Labor Market: Hiring and Training During an Epidemic
Kosali Simon, Herman B. Wells endowed professor in the IU Bloomington O’Neill School of Public and Environmental Affairs; Katy Börner, distinguished professor of information science in the IU Bloomington Luddy School of Informatics, Computing, and Engineering: Analyze novel nationwide geoidentified data systems to provide visualized and actionable evidence to advise policy and economic decision makers, businesses, and local recovery organizations on labor, education, and workforce policy. (P2)
Will Medicare's Recent Coverage of Methadone Help Reduce Racial/Ethnic Gaps in Access to Treatment for Opioid Use Disorder and Health Outcomes?
Kosali Simon, Herman B. Wells endowed professor in the IU Bloomington O'Neill School of Public and Environmental Affairs; Examine the impact of Medicare’s recent policy to reimburse for methadone and other services on racial and ethnic gaps in health outcomes related to opioid use disorder. (REDSURF)
Medicaid Policy: An Opportunity for Racial Equity in Substance Use Disorders Healthcare Access
Kosali Simon, Herman B. Wells endowed professor in the IU Bloomington O’Neill School of Public and Environmental Affairs; Examine whether reducing Medicaid administrative burdens during the COVID Public Health Emergency has narrowed racial and ethnic inequities in health care access. (REDSURF)
Motherhood and Substance Abuse: A Comparison of Racial Differences in Access to Treatment in Northwest Indiana
Monica Solinas-Saunders, associate professor in the School of Public and Environmental Affairs at IU Northwest: Examine the complexity of substance abuse and access to care for individuals who are expectant mothers and mothers (including individuals who identify as non-binary) in the Northwest Indiana region. (REDSURF)
Developing a Better Naloxone
Alex Straiker, senior scientist in the Department of Psychological and Brain Sciences at the IU Bloomington College of Arts and Sciences; Michael Van Nieuwenhze, professor of chemistry in the IU Bloomington College of Arts and Sciences: Provide a more effective antidote for opioid overdoses by developing and testing a better naloxone that works at a second known site of the opioid receptor. (P2)
Monitoring Legal and Policy Interventions and Barriers
Nicolas P. Terry, Hall Render Professor of Law at the McKinney School of Law at IUPUI and executive director, Hall Center for Law and Health; Aila Hoss, visiting assistant professor at the McKinney School of Law at IUPUI: Monitor and assess the impact of various law and policy measures at federal, state, and local levels on the addictions crisis. (P2)
Education and Training in Addictions Counseling
Ellen Vaughan, associate professor of counseling and educational psychology in the IU Bloomington School of Education: Develop and implement an educational program for an addictions counseling certificate and an addictions counseling master's degree to increase the capacity and quality of addictions treatment for Indiana residents and their families. (P1)
Cognitive Behavioral Therapy for Substance Use Disorders
Ellen Vaughan, associate professor of counseling and educational psychology in the IU Bloomington School of Education; Lynn Gilman, clinical assistant professor of counseling and educational psychology in the IU Bloomington School of Education: Implement a randomized controlled trial to test the efficacy of cognitive behavioral therapy (CBT) models for college students with substance use disorders (SUDs), evaluate a group CBT protocol, and assess counselor fidelity to the CBT manual to expand treatment options available for students with SUDs. (P2)
Optimizing Health Among Opioid-Addicted Women and their Children
Sarah Wiehe, associate professor of pediatrics in the IU School of Medicine and director of community health partnerships for the Indiana Clinical and Translational Sciences Institute: Identify the dynamic factors and health services that produce improved health outcomes for opioid-addicted women and their infants with neonatal abstinence syndrome. (P1)
The Long-term Consequences of Opioid Neonatal Abstinence Syndrome
Bryan Yamamoto, chair and professor of pharmacology and toxicology in the IU School of Medicine; Brady Atwood, assistant professor of psychiatry in the IU School of Medicine: Develop an animal model of opioid use disorder to evaluate effects of in utero exposure to opioids and MATs on neonatal and adolescent physiology and behavior in order to inform, guide, and improve clinical practices and to provide direction for long-term care for children exposed in utero to opioids. (P2)
Brief DBT Skills Program to Reduce Adolescent Drug Use in a School-Based Setting
Tamika Zapolski, associate professor of clinical psychology at IUPUI: Analyze the effectiveness of a school-based therapy that has proven effective in clinical settings to reach a broader population of youth at risk for substance abuse. Created program sites in multiple Indianapolis schools; completed 11 groups, made up of 12 students each in grades 7 through 12, to date. (P1)
Provider and Patient Level Factors and Substance Use Disorder Treatment among Black Adults
Tamika Zapolski, associate professor of clinical psychology in the School of Science at IUPUI; Virgil Gregory Jr., associate professor in the IU School of Social Work at IUPUI: Enhance the engagement and completion of substance use disorder (SUD) treatment for Black adults through collaboration with traditional clinic-based agencies and non-traditional community agencies that interact with Black adults with substance use concerns to better understand barriers and facilitators regarding engagement and completion of SUD services for Black adults. (REDSURF)
Implementing Dialectical Behavioral Therapy for Adolescents to Address Substance Use Risk among Youth of Color in a Community Setting
Tamika Zapolski, associate professor of clinical psychology at IUPUI; Test the feasibility and preliminary evidence of the efficacy of a Dialectical Behavioral Therapy for Adolescents (DBT-A) program at reducing substance use and increasing coping skills among youth of color in a community center setting. (REDSURF)
Brief DBT Skills Program to Reduce Adolescent Drug Use in a School-Based Setting: Expansion of Delivery by Staff Working with Virtual School Students
Tamika Zapolski, associate professor of clinical psychology at IUPUI; Test the feasibility of expanding a Dialectical Behavioral Therapy for Adolescents (DBT-A) program to the South Bend Public School System and the YMCA, providing services to a more diverse population of youth who are less likely to receive substance use services and laying the groundwork for the ability to expand the DBT-A program to school systems across the state of Indiana.
YoCo: A Multifaceted Youth Coalition to Decrease Inequity and Disparities in Health Outcomes Among Marginalized Youth
Tamika Zapolski, associate professor of clinical psychology at IUPUI; Develop and implement a youth coalition (YoCo) to increase access to mental health, substance use, education, and employment resources, and decrease risk for negative youth health outcomes among marginalized youth. (REDSURF)